Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study

BACKGROUND: Psychosocial factors including depression, anxiety and lower social support are common in patients with chronic kidney disease (CKD). However the influence of these potentially modifiable risk factors on morbidity and mortality in this renal population is unknown. The Tasmanian Chronic K...

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Autores principales: McKercher, Charlotte M, Venn, Alison J, Blizzard, Leigh, Nelson, Mark R, Palmer, Andrew J, Ashby, Michael A, Scott, Jennifer L, Jose, Matthew D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637060/
https://www.ncbi.nlm.nih.gov/pubmed/23586969
http://dx.doi.org/10.1186/1471-2369-14-83
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author McKercher, Charlotte M
Venn, Alison J
Blizzard, Leigh
Nelson, Mark R
Palmer, Andrew J
Ashby, Michael A
Scott, Jennifer L
Jose, Matthew D
author_facet McKercher, Charlotte M
Venn, Alison J
Blizzard, Leigh
Nelson, Mark R
Palmer, Andrew J
Ashby, Michael A
Scott, Jennifer L
Jose, Matthew D
author_sort McKercher, Charlotte M
collection PubMed
description BACKGROUND: Psychosocial factors including depression, anxiety and lower social support are common in patients with chronic kidney disease (CKD). However the influence of these potentially modifiable risk factors on morbidity and mortality in this renal population is unknown. The Tasmanian Chronic Kidney Disease study is a prospective cohort study which aims to examine the influence of both biomedical and psychosocial factors on disease progression, decision making and length and quality of life in adults with severe CKD, prior to kidney replacement therapy (KRT). This paper describes the recruitment, baseline characteristics and initial follow-up of pilot participants. METHODS: Adults aged > 18 years with stage 4 CKD (eGFR 15–29 mls/min/1.73 m(2)) and not receiving dialysis were recruited via treating physicians. Measures included depression (9-item Patient Health Questionnaire), anxiety (Beck Anxiety Inventory) and social support (Multidimensional Scale of Perceived Social Support). Primary outcomes were kidney disease progression, use of KRT and health-related quality of life (Kidney Disease and Quality of Life Short Form and the EQ-5D). RESULTS: Of those invited (n = 105), 49 provided consent and completed baseline assessment. There were no significant differences between responders and non-responders in age, gender and socio-economic status (all p > 0.05). Participants were predominantly male (63.3%) with a mean age of 72.6 ± 10.2 years. Mean serum creatinine was 241 ± 62 μmol/L with mean eGFR 22 ± 5 mls/min/1.73 m(2). Prevalence of major depression and moderate to severe anxiety was 10% and 9% respectively. Less severe depression and fewer anxiety symptoms were associated with higher health-related quality of life. Follow-up at 10-months showed CKD progression in 34% of participants (use of KRT in 16%, stage 5 CKD without KRT in 18%), one death, with the remainder stable at CKD stage 3 or 4. CONCLUSIONS: Results indicate that a larger prospective study is feasible and has the capacity to examine the influence of biomedical and psychosocial factors on kidney disease progression, use of dialysis and transplantation, and salient personal and economic outcomes. Findings have the potential to provide an evidence base for revising healthcare provision in order to optimize the care of patients with CKD.
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spelling pubmed-36370602013-04-27 Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study McKercher, Charlotte M Venn, Alison J Blizzard, Leigh Nelson, Mark R Palmer, Andrew J Ashby, Michael A Scott, Jennifer L Jose, Matthew D BMC Nephrol Research Article BACKGROUND: Psychosocial factors including depression, anxiety and lower social support are common in patients with chronic kidney disease (CKD). However the influence of these potentially modifiable risk factors on morbidity and mortality in this renal population is unknown. The Tasmanian Chronic Kidney Disease study is a prospective cohort study which aims to examine the influence of both biomedical and psychosocial factors on disease progression, decision making and length and quality of life in adults with severe CKD, prior to kidney replacement therapy (KRT). This paper describes the recruitment, baseline characteristics and initial follow-up of pilot participants. METHODS: Adults aged > 18 years with stage 4 CKD (eGFR 15–29 mls/min/1.73 m(2)) and not receiving dialysis were recruited via treating physicians. Measures included depression (9-item Patient Health Questionnaire), anxiety (Beck Anxiety Inventory) and social support (Multidimensional Scale of Perceived Social Support). Primary outcomes were kidney disease progression, use of KRT and health-related quality of life (Kidney Disease and Quality of Life Short Form and the EQ-5D). RESULTS: Of those invited (n = 105), 49 provided consent and completed baseline assessment. There were no significant differences between responders and non-responders in age, gender and socio-economic status (all p > 0.05). Participants were predominantly male (63.3%) with a mean age of 72.6 ± 10.2 years. Mean serum creatinine was 241 ± 62 μmol/L with mean eGFR 22 ± 5 mls/min/1.73 m(2). Prevalence of major depression and moderate to severe anxiety was 10% and 9% respectively. Less severe depression and fewer anxiety symptoms were associated with higher health-related quality of life. Follow-up at 10-months showed CKD progression in 34% of participants (use of KRT in 16%, stage 5 CKD without KRT in 18%), one death, with the remainder stable at CKD stage 3 or 4. CONCLUSIONS: Results indicate that a larger prospective study is feasible and has the capacity to examine the influence of biomedical and psychosocial factors on kidney disease progression, use of dialysis and transplantation, and salient personal and economic outcomes. Findings have the potential to provide an evidence base for revising healthcare provision in order to optimize the care of patients with CKD. BioMed Central 2013-04-12 /pmc/articles/PMC3637060/ /pubmed/23586969 http://dx.doi.org/10.1186/1471-2369-14-83 Text en Copyright © 2013 McKercher et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
McKercher, Charlotte M
Venn, Alison J
Blizzard, Leigh
Nelson, Mark R
Palmer, Andrew J
Ashby, Michael A
Scott, Jennifer L
Jose, Matthew D
Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study
title Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study
title_full Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study
title_fullStr Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study
title_full_unstemmed Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study
title_short Psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the Tasmanian Chronic Kidney Disease study
title_sort psychosocial factors in adults with chronic kidney disease: characteristics of pilot participants in the tasmanian chronic kidney disease study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637060/
https://www.ncbi.nlm.nih.gov/pubmed/23586969
http://dx.doi.org/10.1186/1471-2369-14-83
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