A Combination of Receptor-Based Pharmacophore Modeling & QM Techniques for Identification of Human Chymase Inhibitors

Inhibition of chymase is likely to divulge therapeutic ways for the treatment of cardiovascular diseases, and fibrotic disorders. To find novel and potent chymase inhibitors and to provide a new idea for drug design, we used both ligand-based and structure-based methods to perform the virtual screen...

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Detalles Bibliográficos
Autores principales: Arooj, Mahreen, Sakkiah, Sugunadevi, Kim, Songmi, Arulalapperumal, Venkatesh, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637262/
https://www.ncbi.nlm.nih.gov/pubmed/23658661
http://dx.doi.org/10.1371/journal.pone.0063030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637262/
https://www.ncbi.nlm.nih.gov/pubmed/23658661
http://dx.doi.org/10.1371/journal.pone.0063030

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