Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis

BACKGROUND: Hypoxia inducible factor-1 α (HIF-1α) has been identified as an important novel target in apoptosis resistance of pediatric tumors such as Rhabdomyosarcoma (RMS) and Ewing’s sarcoma (ES). Evidence suggests that PI3K/Akt signaling plays a role in regulation of HIF-1α activation as well as...

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Detalles Bibliográficos
Autores principales: Kilic-Eren, Mehtap, Boylu, Tulin, Tabor, Vedrana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637483/
https://www.ncbi.nlm.nih.gov/pubmed/23590596
http://dx.doi.org/10.1186/1475-2867-13-36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637483/
https://www.ncbi.nlm.nih.gov/pubmed/23590596
http://dx.doi.org/10.1186/1475-2867-13-36

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