Effects of HDM2 antagonism on sunitinib resistance, p53 activation, SDF-1 induction, and tumor infiltration by CD11b(+)/Gr-1(+) myeloid derived suppressor cells

BACKGROUND: The studies reported herein were undertaken to determine if the angiostatic function of p53 could be exploited as an adjunct to VEGF-targeted therapy in the treatment of renal cell carcinoma (RCC). METHODS: Nude/beige mice bearing human RCC xenografts were treated with various combinatio...

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Detalles Bibliográficos
Autores principales: Panka, David J, Liu, Qingjun, Geissler, Andrew K, Mier, James W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637597/
https://www.ncbi.nlm.nih.gov/pubmed/23497256
http://dx.doi.org/10.1186/1476-4598-12-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637597/
https://www.ncbi.nlm.nih.gov/pubmed/23497256
http://dx.doi.org/10.1186/1476-4598-12-17

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