Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis

Oligodendrocytes associate with axons to establish myelin and provide metabolic support to neurons. In the spinal cord of ALS mice, oligodendrocytes downregulate transporters that transfer glycolytic substrates to neurons and oligodendrocyte progenitors (NG2(+) cells) exhibit enhanced proliferation...

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Detalles Bibliográficos
Autores principales: Kang, Shin H., Li, Ying, Fukaya, Masahiro, Lorenzini, Ileana, Cleveland, Don W., Ostrow, Lyle W., Rothstein, Jeffrey D., Bergles, Dwight E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637847/
https://www.ncbi.nlm.nih.gov/pubmed/23542689
http://dx.doi.org/10.1038/nn.3357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637847/
https://www.ncbi.nlm.nih.gov/pubmed/23542689
http://dx.doi.org/10.1038/nn.3357

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