Physiological Brain Activity Causes DNA Double Strand Breaks in Neurons — Exacerbation by Amyloid-β

We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wildtype mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in spatial learning and memory, and were repaired w...

Descripción completa

Detalles Bibliográficos
Autores principales: Suberbielle, Elsa, Sanchez, Pascal E., Kravitz, Alexxai V., Wang, Xin, Ho, Kaitlyn, Eilertson, Kirsten, Devidze, Nino, Kreitzer, Anatol C., Mucke, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637871/
https://www.ncbi.nlm.nih.gov/pubmed/23525040
http://dx.doi.org/10.1038/nn.3356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637871/
https://www.ncbi.nlm.nih.gov/pubmed/23525040
http://dx.doi.org/10.1038/nn.3356

Ejemplares similares