Stochastic Hypothesis of Transition from Inborn Neutropenia to AML: Interactions of Cell Population Dynamics and Population Genetics

We present a stochastic model of driver mutations in the transition from severe congenital neutropenia to myelodysplastic syndrome to acute myeloid leukemia (AML). The model has the form of a multitype branching process. We derive equations for the distributions of the times to consecutive driver mu...

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Detalles Bibliográficos
Autores principales: Kimmel, Marek, Corey, Seth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638131/
https://www.ncbi.nlm.nih.gov/pubmed/23641360
http://dx.doi.org/10.3389/fonc.2013.00089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638131/
https://www.ncbi.nlm.nih.gov/pubmed/23641360
http://dx.doi.org/10.3389/fonc.2013.00089

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