Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms

Tumor genomes are generally thought to evolve through a gradual accumulation of mutations, but the observation that extraordinarily complex rearrangements can arise through single mutational events suggests that evolution may be accelerated by punctuated changes in genome architecture. To assess the...

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Detalles Bibliográficos
Autores principales: Malhotra, Ankit, Lindberg, Michael, Faust, Gregory G., Leibowitz, Mitchell L., Clark, Royden A., Layer, Ryan M., Quinlan, Aaron R., Hall, Ira M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638133/
https://www.ncbi.nlm.nih.gov/pubmed/23410887
http://dx.doi.org/10.1101/gr.143677.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638133/
https://www.ncbi.nlm.nih.gov/pubmed/23410887
http://dx.doi.org/10.1101/gr.143677.112

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