Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay

Genome-wide chromatin annotations have permitted the mapping of putative regulatory elements across multiple human cell types. However, their experimental dissection by directed regulatory motif disruption has remained unfeasible at the genome scale. Here, we use a massively parallel reporter assay...

Descripción completa

Detalles Bibliográficos
Autores principales: Kheradpour, Pouya, Ernst, Jason, Melnikov, Alexandre, Rogov, Peter, Wang, Li, Zhang, Xiaolan, Alston, Jessica, Mikkelsen, Tarjei S., Kellis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638136/
https://www.ncbi.nlm.nih.gov/pubmed/23512712
http://dx.doi.org/10.1101/gr.144899.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638136/
https://www.ncbi.nlm.nih.gov/pubmed/23512712
http://dx.doi.org/10.1101/gr.144899.112

Ejemplares similares