Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

[Image: see text] Castrate-resistant prostate cancer (CRPC) is a fatal, metastatic form of prostate cancer. CRPC is characterized by reactivation of the androgen axis due to changes in androgen receptor signaling and/or adaptive intratumoral androgen biosynthesis. AKR1C3 is upregulated in CRPC where...

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Detalles Bibliográficos
Autores principales: Liedtke, Andy J., Adeniji, Adegoke O., Chen, Mo, Byrns, Michael C., Jin, Yi, Christianson, David W., Marnett, Lawrence J., Penning, Trevor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638264/
https://www.ncbi.nlm.nih.gov/pubmed/23432095
http://dx.doi.org/10.1021/jm3017656

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638264/
https://www.ncbi.nlm.nih.gov/pubmed/23432095
http://dx.doi.org/10.1021/jm3017656

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