Glucocerebrosidase Deficiency in Substantia Nigra of Parkinson Disease Brains

OBJECTIVE: Mutations in the glucocerebrosidase gene (GBA) represent a significant risk factor for developing Parkinson disease (PD). We investigated the enzymatic activity of glucocerebrosidase (GCase) in PD brains carrying heterozygote GBA mutations (PD+GBA) and sporadic PD brains. METHODS: GCase a...

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Detalles Bibliográficos
Autores principales: Gegg, Matthew E, Burke, Derek, Heales, Simon J R, Cooper, J Mark, Hardy, John, Wood, Nicholas W, Schapira, Anthony H V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638323/
https://www.ncbi.nlm.nih.gov/pubmed/23034917
http://dx.doi.org/10.1002/ana.23614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638323/
https://www.ncbi.nlm.nih.gov/pubmed/23034917
http://dx.doi.org/10.1002/ana.23614

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