Changes in the quaternary structure and function of MjHSP16.5 attributable to deletion of the IXI motif and introduction of the substitution, R107G, in the α-crystallin domain

The archael small heat-shock protein (sHSP), MjHSP16.5, forms a 24-subunit oligomer with octahedral symmetry. Here, we demonstrate that the IXI motif present in the C-terminal domain is necessary for the oligomerization of MjHSP16.5. Removal increased the in vitro chaperone activity with citrate syn...

Descripción completa

Detalles Bibliográficos
Autores principales: Quinlan, Roy A., Zhang, Yan, Lansbury, Andrew, Williamson, Ian, Pohl, Ehmke, Sun, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638399/
https://www.ncbi.nlm.nih.gov/pubmed/23530263
http://dx.doi.org/10.1098/rstb.2012.0327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638399/
https://www.ncbi.nlm.nih.gov/pubmed/23530263
http://dx.doi.org/10.1098/rstb.2012.0327

Ejemplares similares