Cargando…

Molecular Mechanisms of Large-Conductance Ca(2+)-Activated Potassium Channel Activation by Ginseng Gintonin

Gintonin is a unique lysophosphatidic acid (LPA) receptor ligand found in Panax ginseng. Gintonin induces transient [Ca(2+)](i) through G protein-coupled LPA receptors. Large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels are expressed in blood vessels and neurons and play important roles in bl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, S. H., Lee, B. H., Hwang, S. H., Kim, H. J., Lee, S. M., Kim, H. C., Rhim, H. W., Nah, S. Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638619/ https://www.ncbi.nlm.nih.gov/pubmed/23662129 http://dx.doi.org/10.1155/2013/323709

Ejemplares similares

Ginseng Gintonin Activates the Human Cardiac Delayed Rectifier K(+) Channel: Involvement of Ca(2+)/Calmodulin Binding Sites
por: Choi, Sun-Hye, et al.
Publicado: (2014)

Bioactive lipids in gintonin-enriched fraction from ginseng
por: Cho, Hee-Jung, et al.
Publicado: (2019)

Ginseng Gintonin Contains Ligands for GPR40 and GPR55
por: Cho, Yeon-Jin, et al.
Publicado: (2020)

Ginseng gintonin, aging societies, and geriatric brain diseases
por: Choi, Sun-Hye, et al.
Publicado: (2021)

An Edible Gintonin Preparation from Ginseng
por: Choi, Sun-Hye, et al.
Publicado: (2011)

A brief method for preparation of gintonin-enriched fraction from ginseng
por: Choi, Sun-Hye, et al.
Publicado: (2015)

Preparation of Red Ginseng Marc-Derived Gintonin and Its Application as a Skin Nutrient
por: Lee, Rami, et al.
Publicado: (2023)

Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing
por: Kim, Hyeon-Joong, et al.
Publicado: (2017)

Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin
por: Im, Dong-soon, et al.
Publicado: (2013)

Gintonin absorption in intestinal model systems
por: Lee, Byung-Hwan, et al.
Publicado: (2018)

Ginseng pharmacology: a new paradigm based on gintonin-lysophosphatidic acid receptor interactions
por: Choi, Sun-Hye, et al.
Publicado: (2015)

Ginseng Gintonin Enhances Hyaluronic Acid and Collagen Release from Human Dermal Fibroblasts Through Lysophosphatidic Acid Receptor Interaction
por: Lee, Rami, et al.
Publicado: (2019)

A Simple Method for the Preparation of Crude Gintonin from Ginseng Root, Stem, and Leaf
por: Pyo, Mi Kyung, et al.
Publicado: (2011)

Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor
por: Choi, Sun-Hye, et al.
Publicado: (2022)

A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng
por: Lee, Rami, et al.
Publicado: (2023)

Effects of gintonin-enriched fraction on hippocampal gene expressions
por: Lee, Rami, et al.
Publicado: (2021)

Gintonin stimulates autophagic flux in primary cortical astrocytes
por: Rahman, Md. Ataur, et al.
Publicado: (2020)

Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release
por: Lee, Rami, et al.
Publicado: (2021)

Effects of Gintonin-Enriched Fraction on Methylmercury-Induced Neurotoxicity and Organ Methylmercury Elimination
por: Kim, Hyeon-Joong, et al.
Publicado: (2020)

Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca(2+)-Activated Potassium Channel Currents
por: Choi, Sun-Hye, et al.
Publicado: (2013)

Ginseng Gintonin Attenuates Lead-Induced Rat Cerebellar Impairments during Gestation and Lactation
por: Nam, Sung Min, et al.
Publicado: (2020)

Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study
por: Lee, Na-Eun, et al.
Publicado: (2020)

Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe/PSEN-1 double-transgenic mouse model of Αlzheimer's disease
por: Jang, Minhee, et al.
Publicado: (2021)

Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels
por: Tang, Xiang D., et al.
Publicado: (2001)

Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor
por: Nam, Sung Min, et al.
Publicado: (2021)

Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes
por: Lee, Rami, et al.
Publicado: (2021)

Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
por: Kim, Do-Geun, et al.
Publicado: (2021)

Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial
por: Lee, Woo-Jin, et al.
Publicado: (2022)

Gintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB
por: Lim, Hye Kyung, et al.
Publicado: (2022)

Gintonin Isolated from Ginseng Inhibits the Epithelial—Mesenchymal Transition Induced by TGF-β in A549 Lung Cancer Cells
por: Kim, Sung Jin, et al.
Publicado: (2023)

Allosteric Gating of a Large Conductance Ca-activated K(+) Channel
por: Cox, D.H., et al.
Publicado: (1997)

The Gintonin-Enriched Fraction of Ginseng Regulates Lipid Metabolism and Browning via the cAMP-Protein Kinase a Signaling Pathway in Mice White Adipocytes
por: Lee, Kippeum, et al.
Publicado: (2020)

LINGO1 is a regulatory subunit of large conductance, Ca(2+)-activated potassium channels
por: Dudem, Srikanth, et al.
Publicado: (2020)

Gintonin-mediated release of astrocytic vascular endothelial growth factor protects cortical astrocytes from hypoxia-induced cell damages
por: Choi, Sun-Hye, et al.
Publicado: (2019)

Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds.
por: Yun, T K, et al.
Publicado: (2001)

Stimulatory Role of SPAK Signaling in the Regulation of Large Conductance Ca(2+)-Activated Potassium (BK) Channel Protein Expression in Kidney
por: Bi, Ye, et al.
Publicado: (2020)

Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling
por: Hwang, Sung-Hee, et al.
Publicado: (2016)

Intrinsic Voltage Dependence and Ca(2+) Regulation of mslo Large Conductance Ca-activated K(+) Channels
por: Cui, J., et al.
Publicado: (1997)

Gintonin-Induced Wound-Healing-Related Responses Involve Epidermal-Growth-Factor-like Effects in Keratinocytes
por: Won, Kyung-Jong, et al.
Publicado: (2023)

Oxidation modulates LINGO2-induced inactivation of large conductance, Ca(2+)-activated potassium channels
por: Dudem, Srikanth, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0mos4g8loi7gecc53i0qig77t7