Mitochondrial Complex I Inhibitors and Forced Oxidative Phosphorylation Synergize in Inducing Cancer Cell Death

Cancer cells generally rely mostly on glycolysis rather than oxidative phosphorylation (OXPHOS) for ATP production. In fact, they are particularly sensitive to glycolysis inhibition and glucose depletion. On the other hand mitochondrial dysfunctions, involved in the onset of the Warburg effect, are...

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Detalles Bibliográficos
Autores principales: Palorini, Roberta, Simonetto, Tiziana, Cirulli, Claudia, Chiaradonna, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638674/
https://www.ncbi.nlm.nih.gov/pubmed/23690779
http://dx.doi.org/10.1155/2013/243876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638674/
https://www.ncbi.nlm.nih.gov/pubmed/23690779
http://dx.doi.org/10.1155/2013/243876

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