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Progesterone receptor isoforms PRA and PRB differentially contribute to breast cancer cell migration through interaction with focal adhesion kinase complexes

Progesterone receptor (PR) and progestins affect mammary tumorigenesis; however, the relative contributions of PR isoforms A and B (PRA and PRB, respectively) in cancer cell migration remains elusive. By using a bi-inducible MDA-MB-231 breast cancer cell line expressing PRA and/or PRB, we analyzed t...

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Detalles Bibliográficos
Autores principales: Bellance, Catherine, Khan, Junaid A., Meduri, Geri, Guiochon-Mantel, Anne, Lombès, Marc, Loosfelt, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639048/
https://www.ncbi.nlm.nih.gov/pubmed/23485561
http://dx.doi.org/10.1091/mbc.E12-11-0807