Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

OBJECTIVES: Mutations in PTEN inducible kinase-1 (PINK1) induce mitochondrial dysfunction in dopaminergic neurons resulting in an inherited form of Parkinson’s disease. Although PINK1 is present in the heart its exact role there is unclear. We hypothesized that PINK1 protects the heart against acute...

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Detalles Bibliográficos
Autores principales: Siddall, Hilary K., Yellon, Derek M., Ong, Sang-Bing, Mukherjee, Uma A., Burke, Niall, Hall, Andrew R., Angelova, Plamena R., Ludtmann, Marthe H. R., Deas, Emma, Davidson, Sean M., Mocanu, Mihaela M., Hausenloy, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639249/
https://www.ncbi.nlm.nih.gov/pubmed/23638067
http://dx.doi.org/10.1371/journal.pone.0062400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639249/
https://www.ncbi.nlm.nih.gov/pubmed/23638067
http://dx.doi.org/10.1371/journal.pone.0062400

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