Effects of GC Bias in Next-Generation-Sequencing Data on De Novo Genome Assembly

Next-generation-sequencing (NGS) has revolutionized the field of genome assembly because of its much higher data throughput and much lower cost compared with traditional Sanger sequencing. However, NGS poses new computational challenges to de novo genome assembly. Among the challenges, GC bias in NG...

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Detalles Bibliográficos
Autores principales: Chen, Yen-Chun, Liu, Tsunglin, Yu, Chun-Hui, Chiang, Tzen-Yuh, Hwang, Chi-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639258/
https://www.ncbi.nlm.nih.gov/pubmed/23638157
http://dx.doi.org/10.1371/journal.pone.0062856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639258/
https://www.ncbi.nlm.nih.gov/pubmed/23638157
http://dx.doi.org/10.1371/journal.pone.0062856

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