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The Role of Protein Interactions in Mediating Essentiality and Synthetic Lethality
Genes are characterized as essential if their knockout is associated with a lethal phenotype, and these “essential genes” play a central role in biological function. In addition, some genes are only essential when deleted in pairs, a phenomenon known as synthetic lethality. Here we consider genes di...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639263/ https://www.ncbi.nlm.nih.gov/pubmed/23638160 http://dx.doi.org/10.1371/journal.pone.0062866 |