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EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion
Changes in EphA2 signaling can affect cancer cell–cell communication and motility through effects on actomyosin contractility. However, the underlying cell–surface interactions and molecular mechanisms of how EphA2 mediates these effects have remained unclear. We demonstrate here that EphA2 and memb...
Autores principales: | Sugiyama, Nami, Gucciardo, Erika, Tatti, Olga, Varjosalo, Markku, Hyytiäinen, Marko, Gstaiger, Matthias, Lehti, Kaisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639392/ https://www.ncbi.nlm.nih.gov/pubmed/23629968 http://dx.doi.org/10.1083/jcb.201205176 |
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