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Stress granules as crucibles of ALS pathogenesis

Amyotrophic lateral sclerosis (ALS) is a fatal human neurodegenerative disease affecting primarily motor neurons. Two RNA-binding proteins, TDP-43 and FUS, aggregate in the degenerating motor neurons of ALS patients, and mutations in the genes encoding these proteins cause some forms of ALS. TDP-43...

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Detalles Bibliográficos
Autores principales: Li, Yun R., King, Oliver D., Shorter, James, Gitler, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639398/
https://www.ncbi.nlm.nih.gov/pubmed/23629963
http://dx.doi.org/10.1083/jcb.201302044