Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

α-Synuclein is a presynaptic protein that is implicated in Parkinson's and other neurodegenerative diseases. Physiologically, native α-synuclein promotes presynaptic SNARE-complex assembly, but its molecular mechanism of action remains unknown. Here, we found that native α-synuclein promotes cl...

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Detalles Bibliográficos
Autores principales: Diao, Jiajie, Burré, Jacqueline, Vivona, Sandro, Cipriano, Daniel J, Sharma, Manu, Kyoung, Minjoung, Südhof, Thomas C, Brunger, Axel T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639508/
https://www.ncbi.nlm.nih.gov/pubmed/23638301
http://dx.doi.org/10.7554/eLife.00592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639508/
https://www.ncbi.nlm.nih.gov/pubmed/23638301
http://dx.doi.org/10.7554/eLife.00592

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