Antifungal Activity of Fused Mannich Ketones Triggers an Oxidative Stress Response and Is Cap1-Dependent in Candida albicans

We investigated the antifungal activity of fused Mannich ketone (FMK) congeners and two of their aminoalcohol derivatives. In particular, FMKs with five-membered saturated rings were shown to have minimum inhibitory concentration (MIC(90)s) ranging from 0.8 to 6 µg/mL toward C. albicans and the clos...

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Detalles Bibliográficos
Autores principales: Rossignol, Tristan, Kocsis, Béla, Bouquet, Orsolya, Kustos, Ildikó, Kilár, Ferenc, Nyul, Adrien, Jakus, Péter B., Rajbhandari, Kshitij, Prókai, László, d’Enfert, Christophe, Lóránd, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639977/
https://www.ncbi.nlm.nih.gov/pubmed/23646117
http://dx.doi.org/10.1371/journal.pone.0062142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639977/
https://www.ncbi.nlm.nih.gov/pubmed/23646117
http://dx.doi.org/10.1371/journal.pone.0062142

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