A Synthetic Podophyllotoxin Derivative Exerts Anti-Cancer Effects by Inducing Mitotic Arrest and Pro-Apoptotic ER Stress in Lung Cancer Preclinical Models

Some potent chemotherapy drugs including tubulin-binding agents had been developed from nature plants, such as podophyllotoxin and paclitaxel. However, poor cytotoxic selectivity, serious side-effects, and limited effectiveness are still the major concerns in their therapeutic application. We develo...

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Detalles Bibliográficos
Autores principales: Chen, Jia-Yang, Tang, Yen-An, Li, Wen-Shan, Chiou, Yu-Ching, Shieh, Jiunn-Min, Wang, Yi-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639983/
https://www.ncbi.nlm.nih.gov/pubmed/23646116
http://dx.doi.org/10.1371/journal.pone.0062082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639983/
https://www.ncbi.nlm.nih.gov/pubmed/23646116
http://dx.doi.org/10.1371/journal.pone.0062082

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