Evidence for a Pro-Proliferative Feedback Loop in Prostate Cancer: The Role of Epac1 and COX-2-Dependent Pathways

OBJECTIVE: In human prostate cancer cells, a selective Epac agonist, 8-CPT-2Me-cAMP, upregulates cell proliferation and survival via activation of Ras-MAPK and PI- 3-kinase-Akt-mTOR signaling cascades. Here we examine the role of inflammatory mediators in Epac1-induced cellular proliferation by dete...

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Detalles Bibliográficos
Autores principales: Misra, Uma Kant, Pizzo, Salvatore Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640024/
https://www.ncbi.nlm.nih.gov/pubmed/23646189
http://dx.doi.org/10.1371/journal.pone.0063150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640024/
https://www.ncbi.nlm.nih.gov/pubmed/23646189
http://dx.doi.org/10.1371/journal.pone.0063150

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