Cargando…

Structural Insights into a Wildtype Domain of the Oncoprotein E6 and Its Interaction with a PDZ Domain

The high-risk human papilloma virus (HPV) oncoproteins E6 and E7 interact with key cellular regulators and are etiological agents for tumorigenesis and tumor maintenance in cervical cancer and other malignant conditions. E6 induces degradation of the tumor suppressor p53, activates telomerase and de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mischo, André, Ohlenschläger, Oliver, Hortschansky, Peter, Ramachandran, Ramadurai, Görlach, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640046/ https://www.ncbi.nlm.nih.gov/pubmed/23638119 http://dx.doi.org/10.1371/journal.pone.0062584

Ejemplares similares

Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein
por: Genera, Mariano, et al.
Publicado: (2019)

Solution structure of stem-loop α of the hepatitis B virus post-transcriptional regulatory element
por: Schwalbe, Martin, et al.
Publicado: (2008)

Interaction prediction and classification of PDZ domains
por: Kalyoncu, Sibel, et al.
Publicado: (2010)

Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain
por: Araujo-Arcos, Lilian Esmeralda, et al.
Publicado: (2022)

An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein
por: Belyaeva, Tamara A., et al.
Publicado: (2014)

Structure and regulatory role of the C-terminal winged helix domain of the archaeal minichromosome maintenance complex
por: Wiedemann, Christoph, et al.
Publicado: (2015)

A novel cGUUAg tetraloop structure with a conserved yYNMGg-type backbone conformation from cloverleaf 1 of bovine enterovirus 1 RNA
por: Ihle, Yvonne, et al.
Publicado: (2005)

PDZ Domains and Viral Infection: Versatile Potentials of HPV-PDZ Interactions in relation to Malignancy
por: Nagasaka, Kazunori, et al.
Publicado: (2013)

A physical model for PDZ-domain/peptide interactions
por: Kaufmann, Kristian, et al.
Publicado: (2010)

Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain
por: Javorsky, Airah, et al.
Publicado: (2021)

Seeking allosteric networks in PDZ domains
por: Gautier, Candice, et al.
Publicado: (2018)

The Conformational Plasticity Vista of PDZ Domains
por: Murciano-Calles, Javier
Publicado: (2020)

Predicting PDZ domain mediated protein interactions from structure
por: Hui, Shirley, et al.
Publicado: (2013)

Viral Interactions with PDZ Domain-Containing Proteins—An Oncogenic Trait?
por: James, Claire D., et al.
Publicado: (2016)

Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
por: Sundell, Gustav N, et al.
Publicado: (2018)

The PDZ-Binding Motif of HPV16-E6 Oncoprotein Modulates the Keratinization and Stemness Transcriptional Profile In Vivo
por: Cortés-Malagón, Enoc Mariano, et al.
Publicado: (2017)

Genome-Wide Analysis of PDZ Domain Binding Reveals Inherent Functional Overlap within the PDZ Interaction Network
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2011)

Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution
por: Kim, Jinho, et al.
Publicado: (2012)

PDZ and LIM Domain-Encoding Genes: Molecular Interactions and their Role in Development
por: te Velthuis, Aartjan J. W., et al.
Publicado: (2007)

A Specificity Map for the PDZ Domain Family
por: Tonikian, Raffi, et al.
Publicado: (2008)

The PDZ Domain as a Complex Adaptive System
por: Kurakin, Alexei, et al.
Publicado: (2007)

Application of Wavelet Transform for PDZ Domain Classification
por: Daqrouq, Khaled, et al.
Publicado: (2015)

Plasticity of PDZ domains in ligand recognition and signaling
por: Ivarsson, Ylva
Publicado: (2012)

Resonance assignment of the Shank1 PDZ domain
por: Sánta, Anna, et al.
Publicado: (2022)

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein
por: Marsh, Elizabeth K., et al.
Publicado: (2017)

PDZ Domain Recognition: Insight from Human Tax-Interacting Protein 1 (TIP-1) Interaction with Target Proteins
por: Mohanty, Smita, et al.
Publicado: (2015)

The N-terminus of the human RecQL4 helicase is a homeodomain-like DNA interaction motif
por: Ohlenschläger, Oliver, et al.
Publicado: (2012)

Proteome scanning to predict PDZ domain interactions using support vector machines
por: Hui, Shirley, et al.
Publicado: (2010)

Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-β-synthase
por: Kumar, Amit, et al.
Publicado: (2018)

PDZ domains and their binding partners: structure, specificity, and modification
por: Lee, Ho-Jin, et al.
Publicado: (2010)

Membrane Binding and Modulation of the PDZ Domain of PICK1
por: Erlendsson, Simon, et al.
Publicado: (2015)

Phosphorylation-induced changes in the PDZ domain of Dishevelled 3
por: Jurásek, Miroslav, et al.
Publicado: (2021)

Domain Analysis and Motif Matcher (DAMM): A Program to Predict Selectivity Determinants in Monosiga brevicollis PDZ Domains Using Human PDZ Data
por: Wofford, Haley A., et al.
Publicado: (2021)

Accurate Prediction of the Dynamical Changes within the Second PDZ Domain of PTP1e
por: Cilia, Elisa, et al.
Publicado: (2012)

Modular organization of the PDZ domains in the human discs-large protein suggests a mechanism for coupling PDZ domain-binding proteins to ATP and the membrane cytoskeleton
Publicado: (1996)

Accidental Interaction between PDZ Domains and Diclofenac Revealed by NMR-Assisted Virtual Screening
por: Tenno, Takeshi, et al.
Publicado: (2013)

Dishevelled-1 DIX and PDZ domain lysine residues regulate oncogenic Wnt signaling
por: Sharma, Monica, et al.
Publicado: (2021)

Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR
por: Wiedemann, Christoph, et al.
Publicado: (2020)

The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains
por: Münz, Márton, et al.
Publicado: (2012)

Role of Terahertz (THz) Fluctuations in the Allosteric Properties of the PDZ Domains
por: Conti Nibali, Valeria, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gaqbqn7uv4jtour6tfb2dkif8m