Detection of clonal T-cell-receptor (TCR) Vbeta rearrangements in explanted dilated cardiomyopathy hearts by semi-nested PCR, GeneScan, and direct sequencing

BACKGROUND: Viral infection and anti-cardiac immunity are involved in the pathogenesis of dilated cardiomyopathy (DCM). Immunity targeting particular antigens may evoke expansion of reactive T-cell clones. MATERIAL/METHODS: Myocardial tissues from explanted hearts were investigated for clonal T-cell...

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Detalles Bibliográficos
Autores principales: Blohm, Jan-Henrik, Blohm, Nadine, Hummel, Michael, Müller, Hans-Henning, Rohde, Maria, Hetzer, Roland, Lehmkuhl, Hans, Noutsias, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
In Vitro / In Vivo Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640101/
https://www.ncbi.nlm.nih.gov/pubmed/23524509
http://dx.doi.org/10.12659/MSMBR.883851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640101/
https://www.ncbi.nlm.nih.gov/pubmed/23524509
http://dx.doi.org/10.12659/MSMBR.883851

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