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Phosphorylated CaMKII levels increase in rat central nervous system after large-dose intravenous remifentanil

BACKGROUND: Postoperative remifentanil-induced pain sensitization is common, but its molecular mechanism remains unclear. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been shown to have a critical role in morphine-induced hyperalgesia. This study was designed to determine how CaMKII p...

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Detalles Bibliográficos
Autores principales: Wang, Qiang, Zhao, Xin, Li, Shuren, Han, Song, Peng, Zhifeng, Li, Junfa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640102/
https://www.ncbi.nlm.nih.gov/pubmed/23549416
http://dx.doi.org/10.12659/MSMBR.883866