Iodinin (1,6-Dihydroxyphenazine 5,10-Dioxide) from Streptosporangium sp. Induces Apoptosis Selectively in Myeloid Leukemia Cell Lines and Patient Cells

Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacterium for the ability to induce cell death in a range...

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Detalles Bibliográficos
Autores principales: Myhren, Lene E., Nygaard, Gyrid, Gausdal, Gro, Sletta, Håvard, Teigen, Knut, Degnes, Kristin F., Zahlsen, Kolbjørn, Brunsvik, Anders, Bruserud, Øystein, Døskeland, Stein Ove, Selheim, Frode, Herfindal, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640383/
https://www.ncbi.nlm.nih.gov/pubmed/23364682
http://dx.doi.org/10.3390/md11020332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640383/
https://www.ncbi.nlm.nih.gov/pubmed/23364682
http://dx.doi.org/10.3390/md11020332

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