Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

ERK1/2 kinases are the principal effectors of a central signaling cascade that converts extracellular stimuli into cell proliferation and migration responses and, when deregulated, can promote cell oncogenic transformation. The scaffolding protein PEA-15 is a death effector domain (DED) protein that...

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Detalles Bibliográficos
Autores principales: Mace, Peter D., Wallez, Yann, Egger, Michael F., Dobaczewska, Małgorzata K., Robinson, Howard, Pasquale, Elena B., Riedl, Stefan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640864/
https://www.ncbi.nlm.nih.gov/pubmed/23575685
http://dx.doi.org/10.1038/ncomms2687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640864/
https://www.ncbi.nlm.nih.gov/pubmed/23575685
http://dx.doi.org/10.1038/ncomms2687

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