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Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK
ERK1/2 kinases are the principal effectors of a central signaling cascade that converts extracellular stimuli into cell proliferation and migration responses and, when deregulated, can promote cell oncogenic transformation. The scaffolding protein PEA-15 is a death effector domain (DED) protein that...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640864/ https://www.ncbi.nlm.nih.gov/pubmed/23575685 http://dx.doi.org/10.1038/ncomms2687 |