Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia

BACKGROUND: The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in prostate cancer. We examined Vav3 small interfering RNA (siRNA) effects on cell prolife...

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Detalles Bibliográficos
Autores principales: Nomura, Takeo, Yamasaki, Mutsushi, Hirai, Kenichi, Inoue, Toru, Sato, Ryuta, Matsuura, Keiko, Moriyama, Masatsugu, Sato, Fuminori, Mimata, Hiromitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640915/
https://www.ncbi.nlm.nih.gov/pubmed/23566222
http://dx.doi.org/10.1186/1476-4598-12-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640915/
https://www.ncbi.nlm.nih.gov/pubmed/23566222
http://dx.doi.org/10.1186/1476-4598-12-27

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