Cargando…

Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia

BACKGROUND: The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in prostate cancer. We examined Vav3 small interfering RNA (siRNA) effects on cell prolife...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nomura, Takeo, Yamasaki, Mutsushi, Hirai, Kenichi, Inoue, Toru, Sato, Ryuta, Matsuura, Keiko, Moriyama, Masatsugu, Sato, Fuminori, Mimata, Hiromitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640915/ https://www.ncbi.nlm.nih.gov/pubmed/23566222 http://dx.doi.org/10.1186/1476-4598-12-27

Ejemplares similares

Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells
por: SATO, RYUTA, et al.
Publicado: (2015)

A Case of Large Solitary Fibrous Tumor in the Retroperitoneum
por: Nomura, Takeo, et al.
Publicado: (2009)

Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer
por: MA, LIANG, et al.
Publicado: (2014)

Alteration of Androgen Receptor Protein Stability by Triptolide in LNCaP Cells
por: Li, Wei, et al.
Publicado: (2018)

Androgen-independent LNCaP cells are a subline of LNCaP cells with a more aggressive phenotype and androgen suppresses their growth by inducing cell cycle arrest at the G1 phase
por: Yu, Pan, et al.
Publicado: (2017)

Androgen upregulates the palmitoylation of eIF3L in human prostate LNCaP cells
por: Cui, Luwei, et al.
Publicado: (2019)

Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma
por: Takahashi, Mika, et al.
Publicado: (2016)

ADAMTS1 alters blood vessel morphology and TSP1 levels in LNCaP and LNCaP-19 prostate tumors
por: Gustavsson, Heléne, et al.
Publicado: (2010)

Synthetic androgens suppress the transformed phenotype in the human prostate carcinoma cell line LNCaP.
por: Wolf, D. A., et al.
Publicado: (1991)

Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenografts
por: Hong, Jeong Hee, et al.
Publicado: (2015)

Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence
por: Dahl, Haley C., et al.
Publicado: (2020)

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma
por: Matsuura, Keiko, et al.
Publicado: (2011)

Downregulation of NDUFB6 due to 9p24.1-p13.3 loss is implicated in metastatic clear cell renal cell carcinoma
por: Narimatsu, Takahiro, et al.
Publicado: (2015)

Role of Androgen Receptor in Progression of LNCaP Prostate Cancer Cells from G(1) to S Phase
por: Murthy, Shalini, et al.
Publicado: (2013)

Enhanced sensitivity to androgen withdrawal due to overexpression of interleukin-6 in androgen-dependent human prostate cancer LNCaP cells
por: Terakawa, T, et al.
Publicado: (2009)

Laparoendoscopic Single-Site (LESS) Retroperitoneal Radical Nephrectomy in a Patient with Renal Cell Carcinoma Receiving Hemodialysis
por: Nomura, Takeo, et al.
Publicado: (2011)

Lymphoepithelioma-Like Carcinoma of the Bladder: A Case Report and Review of the Literature
por: Mori, Kenichi, et al.
Publicado: (2013)

CRISPR/Cas9 targeting of the androgen receptor suppresses the growth of LNCaP human prostate cancer cells
por: Wei, Chaogang, et al.
Publicado: (2018)

Ophiopogonin D' induces RIPK1-dependent necroptosis in androgen-dependent LNCaP prostate cancer cells
por: Lu, Zongliang, et al.
Publicado: (2019)

Efficacy of PACE4 pharmacotherapy in JHU-LNCaP-SM preclinical model of androgen independent prostate cancer
por: Mekdad, Nawel, et al.
Publicado: (2022)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: ZHANG, XIANQING, et al.
Publicado: (2014)

Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo
por: Zhang, Xianqing, et al.
Publicado: (2018)

Optimal timing and dosage of chemotherapy as a combined treatment with androgen withdrawal in the human prostate LNCaP tumour model
por: Miyake, H, et al.
Publicado: (2001)

Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells
por: Kita, Kazuaki, et al.
Publicado: (2017)

Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
por: Alafnan, Ahmed, et al.
Publicado: (2023)

Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling
por: TILLI, TATIANA MARTINS, et al.
Publicado: (2015)

Calcitriol and TO-901317 Interact in Human Prostate Cancer LNCaP Cells
por: Wang, Jing-Huan, et al.
Publicado: (2008)

URG11 promotes proliferation and induced apoptosis of LNCaP cells
por: Sun, Chenmin, et al.
Publicado: (2019)

HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling
por: Kim, Young-Rang, et al.
Publicado: (2010)

Down-regulation of DcR2 sensitizes androgen-dependent prostate cancer LNCaP cells to TRAIL-induced apoptosis
por: Vindrieux, David, et al.
Publicado: (2011)

Corrigendum: Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells
por: Alafnan, Ahmed, et al.
Publicado: (2023)

Left Transperitoneal Adrenalectomy with a Laparoendoscopic Single-Site Surgery Combined Technique: Initial Case Reports
por: Sumino, Yasuhiro, et al.
Publicado: (2011)

Correlation Between PSMA and VEGF Expression as Markers for LNCaP Tumor Angiogenesis
por: Tsui, Paulus, et al.
Publicado: (2005)

Anti-Cancer Effect of Lambertianic Acid by Inhibiting the AR in LNCaP Cells
por: Lee, Myoung-Sun, et al.
Publicado: (2016)

Androgen Receptor Activity Is Affected by Both Nuclear Matrix Localization and the Phosphorylation Status of the Heterogeneous Nuclear Ribonucleoprotein K in Anti-Androgen-Treated LNCaP Cells
por: Barboro, Paola, et al.
Publicado: (2013)

Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome
por: Rajan, Prabhakar, et al.
Publicado: (2011)

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells
por: Lu, Lifang, et al.
Publicado: (2002)

Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition
por: Byrne, N M, et al.
Publicado: (2016)

Role of Testosterone Levels on the Combinatorial Effect of Boswellia serrata Extract and Enzalutamide on Androgen Dependent LNCaP Cells and in Patient Derived Cells
por: Pillai, Prathesha, et al.
Publicado: (2021)

Inhibition of Androgen Receptor Expression with Small Interfering RNA Enhances Cancer Cell Apoptosis by Suppressing Survival Factors in Androgen Insensitive, Late Stage LNCaP Cells
por: Kim, Sang Soo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gs0r8cic8ug7iupj9panco5fl5