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Sos-mediated cross activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
Mammalian cells contain three closely related ras genes, H-ras, K-ras and N-ras. Although, in a given tumor type, oncogenic mutations are selectively observed in only one of the ras genes, the acquisition of the transformed phenotype has been shown to require the contribution of the normal products...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640996/ https://www.ncbi.nlm.nih.gov/pubmed/23132018 http://dx.doi.org/10.1038/ncomms2173 |