Targeting Mitochondrial STAT3 with the Novel Phospho-Valproic Acid (MDC-1112) Inhibits Pancreatic Cancer Growth in Mice

New agents are needed to treat pancreatic cancer, one of the most lethal human malignancies. We synthesized phospho-valproic acid, a novel valproic acid derivative, (P-V; MDC-1112) and evaluated its efficacy in the control of pancreatic cancer. P-V inhibited the growth of human pancreatic cancer xen...

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Detalles Bibliográficos
Autores principales: Mackenzie, Gerardo G., Huang, Liqun, Alston, Ninche, Ouyang, Nengtai, Vrankova, Kvetoslava, Mattheolabakis, George, Constantinides, Panayiotis P., Rigas, Basil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641121/
https://www.ncbi.nlm.nih.gov/pubmed/23650499
http://dx.doi.org/10.1371/journal.pone.0061532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641121/
https://www.ncbi.nlm.nih.gov/pubmed/23650499
http://dx.doi.org/10.1371/journal.pone.0061532

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