Novel Insulin Sensitizer Modulates Nutrient Sensing Pathways and Maintains β-Cell Phenotype in Human Islets

Major bottlenecks in the expansion of human β-cell mass are limited proliferation, loss of β-cell phenotype, and increased apoptosis. In our previous studies, activation of Wnt and mTOR signaling significantly enhanced human β-cell proliferation. However, isolated human islets displayed insulin sign...

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Detalles Bibliográficos
Autores principales: Rohatgi, Nidhi, Aly, Haytham, Marshall, Connie A., McDonald, William G., Kletzien, Rolf F., Colca, Jerry R., McDaniel, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641131/
https://www.ncbi.nlm.nih.gov/pubmed/23650507
http://dx.doi.org/10.1371/journal.pone.0062012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641131/
https://www.ncbi.nlm.nih.gov/pubmed/23650507
http://dx.doi.org/10.1371/journal.pone.0062012

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