Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases

Although statins are known to inhibit proliferation and induce death in a number of cancer cell types, the mechanisms through which downregulation of the mevalonate (MVA) pathway activates death signaling remain poorly understood. Here we set out to unravel the signaling networks downstream of the M...

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Detalles Bibliográficos
Autores principales: Zhu, Y, Casey, P J, Kumar, A P, Pervaiz, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641326/
https://www.ncbi.nlm.nih.gov/pubmed/23559002
http://dx.doi.org/10.1038/cddis.2013.103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641326/
https://www.ncbi.nlm.nih.gov/pubmed/23559002
http://dx.doi.org/10.1038/cddis.2013.103

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