E6AP, an E3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C/EBPα for ubiquitin-mediated proteasome degradation

CCAAT/enhancer-binding protein alpha (C/EBPα) is an important transcription factor involved in granulocytic differentiation. Here, for the first time we demonstrate that E6-associated protein (E6AP), an E3 ubiquitin ligase targets C/EBPα for ubiquitin-mediated proteasome degradation and thereby nega...

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Detalles Bibliográficos
Autores principales: Pal, P, Lochab, S, Kanaujiya, J K, Kapoor, I, Sanyal, S, Behre, G, Trivedi, A K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641343/
https://www.ncbi.nlm.nih.gov/pubmed/23598402
http://dx.doi.org/10.1038/cddis.2013.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641343/
https://www.ncbi.nlm.nih.gov/pubmed/23598402
http://dx.doi.org/10.1038/cddis.2013.120

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