NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss

Aggregates of amyloid-beta (Aβ) and tau are hallmarks of Alzheimer's disease (AD) leading to neurodegeneration and synaptic loss. While increasing evidence suggests that inhibition of N-methyl-𝒟-aspartate receptors (NMDARs) may mitigate certain aspects of AD neuropathology, the precise role of...

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Detalles Bibliográficos
Autores principales: Tackenberg, C, Grinschgl, S, Trutzel, A, Santuccione, A C, Frey, M C, Konietzko, U, Grimm, J, Brandt, R, Nitsch, R M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641351/
https://www.ncbi.nlm.nih.gov/pubmed/23618906
http://dx.doi.org/10.1038/cddis.2013.129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641351/
https://www.ncbi.nlm.nih.gov/pubmed/23618906
http://dx.doi.org/10.1038/cddis.2013.129

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