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Identification of tumorigenic and therapeutically actionable mutations in transplantable mouse tumor cells by exome sequencing
Cancer development occurs in response to the successive accumulation of mutations that eventually targets key regulators of cell proliferation. As most mutations likely occur randomly, cancer driver mutations can only be found if they are recurrent. Here we use exome sequencing of the mouse cell lin...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641362/ https://www.ncbi.nlm.nih.gov/pubmed/23588493 http://dx.doi.org/10.1038/oncsis.2013.8 |