Wnt Signaling Regulates the Lineage Differentiation Potential of Mouse Embryonic Stem Cells through Tcf3 Down-Regulation

Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously shown that mutation in the Apc (adenomatous polyposis coli) tumor suppressor gene constitutively activates Wnt signaling in ESCs and inhibits the...

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Detalles Bibliográficos
Autores principales: Atlasi, Yaser, Noori, Rubina, Gaspar, Claudia, Franken, Patrick, Sacchetti, Andrea, Rafati, Haleh, Mahmoudi, Tokameh, Decraene, Charles, Calin, George A., Merrill, Bradley J., Fodde, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642041/
https://www.ncbi.nlm.nih.gov/pubmed/23658527
http://dx.doi.org/10.1371/journal.pgen.1003424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642041/
https://www.ncbi.nlm.nih.gov/pubmed/23658527
http://dx.doi.org/10.1371/journal.pgen.1003424

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