IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination

The insulin like growth factor receptor subtype 1(IGF-1R) plays an important role in cancers transformation and progression. The aim is to investigate the effects of sunitinib on IGF-1R cell signaling transduction, especially on receptor phosphorylation and ubiquitination. In HEK293 cells, IGF-1R si...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Hongchang, Fang, Yan, Dong, Wei, Mu, Xueru, Liu, Qi, Du, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642090/
https://www.ncbi.nlm.nih.gov/pubmed/23650573
http://dx.doi.org/10.1016/j.fob.2011.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642090/
https://www.ncbi.nlm.nih.gov/pubmed/23650573
http://dx.doi.org/10.1016/j.fob.2011.12.001

Ejemplares similares