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IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination
The insulin like growth factor receptor subtype 1(IGF-1R) plays an important role in cancers transformation and progression. The aim is to investigate the effects of sunitinib on IGF-1R cell signaling transduction, especially on receptor phosphorylation and ubiquitination. In HEK293 cells, IGF-1R si...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642090/ https://www.ncbi.nlm.nih.gov/pubmed/23650573 http://dx.doi.org/10.1016/j.fob.2011.12.001 |