Effects of Targeted Suppression of Glutaryl-CoA Dehydrogenase by Lentivirus-Mediated shRNA and Excessive Intake of Lysine on Apoptosis in Rat Striatal Neurons

In glutaric aciduria type 1 (GA1), glutaryl-CoA dehydrogenase (GCDH) deficiency has been shown to be responsible for the accumulation of glutaric acid and striatal degeneration. However, the mechanisms by which GA1 induces striatal degeneration remain unclear. In this study, we aimed to establish a...

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Detalles Bibliográficos
Autores principales: Gao, Jinzhi, Zhang, Cai, Fu, Xi, Yi, Qin, Tian, Fengyan, Ning, Qin, Luo, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642093/
https://www.ncbi.nlm.nih.gov/pubmed/23658800
http://dx.doi.org/10.1371/journal.pone.0063084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642093/
https://www.ncbi.nlm.nih.gov/pubmed/23658800
http://dx.doi.org/10.1371/journal.pone.0063084

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