The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1

The Wnt pathway regulates cell proliferation, mobility and differentiation. Among the many Wnt target genes is CCND1 which codes for cyclin D1. Cyclin D1, in complex with cdk4 and cdk6, regulates G1/S phase transition during cell cycle. Independently of CDK, cyclin D1 also regulates the migration of...

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Detalles Bibliográficos
Autores principales: Vlad-Fiegen, Annica, Langerak, Anette, Eberth, Sonja, Müller, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642111/
https://www.ncbi.nlm.nih.gov/pubmed/23650577
http://dx.doi.org/10.1016/j.fob.2012.02.004
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author Vlad-Fiegen, Annica
Langerak, Anette
Eberth, Sonja
Müller, Oliver
author_facet Vlad-Fiegen, Annica
Langerak, Anette
Eberth, Sonja
Müller, Oliver
author_sort Vlad-Fiegen, Annica
collection PubMed
description The Wnt pathway regulates cell proliferation, mobility and differentiation. Among the many Wnt target genes is CCND1 which codes for cyclin D1. Cyclin D1, in complex with cdk4 and cdk6, regulates G1/S phase transition during cell cycle. Independently of CDK, cyclin D1 also regulates the migration of macrophages. Here we analyzed the effects of cyclin D1 on the migration of cancer cell lines using the transwell migration and scratch assays. We also tested the effect of cyclin D1 and β-catenin on E-cadherin-mediated cell–cell contacts. Our results show that the Wnt pathway promotes cellular migration via its target gene cyclin D1. Moreover we show that cyclin D1 influences the actin cytoskeleton and destabilizes adherens junctions.
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spelling pubmed-36421112013-05-06 The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1 Vlad-Fiegen, Annica Langerak, Anette Eberth, Sonja Müller, Oliver FEBS Open Bio Article The Wnt pathway regulates cell proliferation, mobility and differentiation. Among the many Wnt target genes is CCND1 which codes for cyclin D1. Cyclin D1, in complex with cdk4 and cdk6, regulates G1/S phase transition during cell cycle. Independently of CDK, cyclin D1 also regulates the migration of macrophages. Here we analyzed the effects of cyclin D1 on the migration of cancer cell lines using the transwell migration and scratch assays. We also tested the effect of cyclin D1 and β-catenin on E-cadherin-mediated cell–cell contacts. Our results show that the Wnt pathway promotes cellular migration via its target gene cyclin D1. Moreover we show that cyclin D1 influences the actin cytoskeleton and destabilizes adherens junctions. Elsevier 2012-03-05 /pmc/articles/PMC3642111/ /pubmed/23650577 http://dx.doi.org/10.1016/j.fob.2012.02.004 Text en © 2012 Published by Elsevier B.V. on behalf of Federation of European Biochemical Societies. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non- commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Vlad-Fiegen, Annica
Langerak, Anette
Eberth, Sonja
Müller, Oliver
The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1
title The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1
title_full The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1
title_fullStr The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1
title_full_unstemmed The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1
title_short The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1
title_sort wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin d1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642111/
https://www.ncbi.nlm.nih.gov/pubmed/23650577
http://dx.doi.org/10.1016/j.fob.2012.02.004
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