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Mithramycin Targets Sp1 and The Androgen Receptor Transcription Level—Potential Therapeutic Role in Advanced Prostate Cancer
Multiple lines of evidence implicate over-expression and activation of the androgen receptor (AR) in the progression of prostate cancer (PC) to androgen-independence (AI) and resistance to therapy. The mechanisms leading to AR over-expression are not fully understood but binding of Sp1 to specific S...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Libertas Academica
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642134/ https://www.ncbi.nlm.nih.gov/pubmed/23662037 |