The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism

Isocitrate dehydrogenase (IDH) catalyzes the oxidative NAD(P)(+)-dependent decarboxylation of isocitrate into α-ketoglutarate and CO(2) and is present in organisms spanning the biological range of temperature. We have solved two crystal structures of the thermophilic Clostridium thermocellum IDH (Ct...

Descripción completa

Detalles Bibliográficos
Autores principales: Leiros, Hanna-Kirsti S., Fedøy, Anita-Elin, Leiros, Ingar, Steen, Ida Helene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642140/
https://www.ncbi.nlm.nih.gov/pubmed/23650595
http://dx.doi.org/10.1016/j.fob.2012.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642140/
https://www.ncbi.nlm.nih.gov/pubmed/23650595
http://dx.doi.org/10.1016/j.fob.2012.06.003

Ejemplares similares