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Bacterial biosensors for screening isoform-selective ligands for human thyroid receptors α-1 and β-1
Subtype-selective thyromimetics have potential as new pharmaceuticals for the prevention or treatment of heart disease, high LDL cholesterol and obesity, but there are only a few methods that can detect agonistic behavior of TR-active compounds. Among these are the rat pituitary GH(3) cell assay and...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642162/ https://www.ncbi.nlm.nih.gov/pubmed/23667826 http://dx.doi.org/10.1016/j.fob.2012.08.002 |