Distinct Structural Features of G Protein-Coupled Receptor Kinase 5 (GRK5) Regulate Its Nuclear Localization and DNA-Binding Ability

G protein-coupled receptor kinases (GRKs) act to desensitize G protein-coupled receptors (GPCRs). In addition to this role at the plasma membrane, a nuclear function for GRK5, a member of the GRK4 subfamily of GRKs, has been reported. GRK5 phosphorylates and promotes the nuclear export of the histon...

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Detalles Bibliográficos
Autores principales: Johnson, Laura R., Robinson, James D., Lester, Katrina N., Pitcher, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642199/
https://www.ncbi.nlm.nih.gov/pubmed/23658733
http://dx.doi.org/10.1371/journal.pone.0062508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642199/
https://www.ncbi.nlm.nih.gov/pubmed/23658733
http://dx.doi.org/10.1371/journal.pone.0062508

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