Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair

DNA polymerase III (Pol III) is the catalytic α subunit of the bacterial DNA Polymerase III holoenzyme. To reach maximum activity, Pol III binds to the DNA sliding clamp β and the exonuclease ε that provide processivity and proofreading, respectively. Here, we characterize the architecture of the Po...

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Detalles Bibliográficos
Autores principales: Toste Rêgo, Ana, Holding, Andrew N, Kent, Helen, Lamers, Meindert H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642679/
https://www.ncbi.nlm.nih.gov/pubmed/23549287
http://dx.doi.org/10.1038/emboj.2013.68

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642679/
https://www.ncbi.nlm.nih.gov/pubmed/23549287
http://dx.doi.org/10.1038/emboj.2013.68

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