Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes

CpG islands are GC-rich regions often located in the 5′ end of genes and normally protected from cytosine methylation in mammals. The important role of CpG islands in gene transcription strongly suggests evolutionary conservation in the mammalian genome. However, as CpG dinucleotides are over-repres...

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Detalles Bibliográficos
Autores principales: Chae, Heejoon, Park, Jinwoo, Lee, Seong-Whan, Nephew, Kenneth P., Kim, Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643570/
https://www.ncbi.nlm.nih.gov/pubmed/23519616
http://dx.doi.org/10.1093/nar/gkt144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643570/
https://www.ncbi.nlm.nih.gov/pubmed/23519616
http://dx.doi.org/10.1093/nar/gkt144

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